Analysis of the intersection of the different anti-Ro52 antibodies revealed that 88% (65 of 74) of patients with SLE positive for anti-Ro52‘classic’ antibodies are also positive for anti-Ro52Ex4 antibodies (Figure 5E), demonstrating that positivity to anti-Ro52Ex4 antibodies identifies the majority of anti-Ro52‘classic’ antibodies in SLE. The gene discussed is TRIM21; the disease is systemic lupus erythematosus.