LOX and melanoma: Using a total of 6 melanoma cell lines (Supplemental Figure 2), we found that the SOX10– cell lines (IGR-39, LOX, A7) had an increase in proliferative capacity after 96 hours in culture as compared with the SOX10+ cell lines (MM383, WM278, WM852) (Figure 3A, P = 0.0001; Supplemental Figure 3, P < 0.001).