SOX10 and melanoma: Strikingly, the primary tumors from NSG mice transplanted with SOX10+ MM383 melanoma cells showed variable shapes (mono-/bi-/multi-lobar), densities (solid/spongy/soft), and necrotic features, while the nonpigmented primary tumors from SOX10– IGR-39 injected NSG mice were consistently characterized by confined margin, rounded shape, and clear color (Figure 4A).