Severe hypoglycemia results in 242 000 emergency department visits annually.1 More than 20% of patients with type 2 diabetes and all patients with type 1 diabetes in the United States are at risk of severe hypoglycemia due to insulin or sulfonylurea use.2 Glucagon is a life-saving medication for emergency treatment of severe hypoglycemia that can be administered outside of health care settings, where most episodes occur. The gene discussed is INS; the disease is Hypoglycemia.