hsa-miR-181c-5p and hsa-miR-20a-5p were downregulated in AD patients and targeted both the transcription factors RORA that negatively regulated BDNF as well as MeCP2 whose upregulation further reduces the level of BDNF, thereby aggravating cognitive decline in AD patients (Fig. 5E). The gene discussed is RORA; the disease is Alzheimer disease.