MECP2 and Alzheimer disease: Methyl-CpG binding protein 2 (MeCP2), which was targeted by hsa-miR-181c-5p (Fig. 4K) and upregulated in AD patients, repressed α-secretase, ADAM metallopeptidase domain 10 (ADAM10), to improve Aβ generation (Fig. 4L) [45].