Assuming that similar projection patterns of LC exist in mammalian species including human, the referred tracing studies together with our results indicate that the dorsal LC with more advanced tau cytoskeletal pathological lesions already in the precortical Braak 0 stage project to regions of the brain that are strongly affected by AD pathology, like the hippocampus or neocortex [59]. Here, MAPT is linked to Alzheimer disease.