This cross-sectional study aimed to describe NVC findings in sarcoidosis and report the prevalence of serum positivity for anti-nuclear (ANA) and extractable nuclear antigen (ENA) autoantibodies in sarcoidosis patients, comparing them with age- and sex- matched healthy controls (HCs) and with patients with primary Raynaud’s phenomenon (PRP). This evidence concerns the gene BTG3 and sarcoidosis.