WNT3 and cancer: To compare the molecular mechanism concerning the cytoneme-mediated Wnt3 dissemination in gastric epithelium cells and GC cells, we investigated the function of Flot2, a scaffolding protein, which enhances the generation of filopodia-like structures in various cancer cell lines (Neumann-Giesen et al., 2004) and is highly expressed in GC (Cao et al., 2013; Zhu et al., 2013).