WLS and digestive system adenoma: In gastrointestinal adenomas and differentiated carcinomas, Wnt3 and Wnt cargo receptor Evi/Wntless are significantly increased and crucial for cancer cell proliferation and colony formation (Voloshanenko et al., 2013), and we show that Wnt3 and Evi/Wntless co-localise on cytonemes (Figure 1).