IL1B and Alzheimer disease: It is noteworthy that previous studies have shown that IL-1β and IL-6 play an important role in the progression of AD, as both were released from microglial cells surrounding Aβ plaques in AD patients and animal models (Wang et al., 2015; Boutajangout and Wisniewski, 2013; Hunter et al., 2012; Vukic et al., 2009).