Recombinant human IL-37 has protective effects against endotoxemia, acute lung and spinal cord injury, asthma, and myocardial infarction (Cavalli et al., 2016; Cavalli and Dinarello, 2018; Coll-Miró et al., 2016; Moretti et al., 2014; Wu et al., 2014; Li et al., 2015; Lunding et al., 2015; Ye et al., 2014). Here, IL37 is linked to serum lipopolysaccharide activity.