IL37 and early-onset autosomal dominant Alzheimer disease: To investigate the potential of IL-37 to attenuate chronic inflammation, we next analyzed transgenic APP/PS1 mice, which serve as a widely used animal model for Alzheimer’s disease (Jankowsky et al., 2004), and crossed this mouse strain with hIL-37tg animals (Figure 6A; Nold et al., 2010).