EPAS1 and hemangioblastoma: While there is only a single case of hemangioblastoma linked to a HIF2α gain-of-function mutation, a unique and uncharacterized double F374Y and Q561K missense mutation, (Taieb et al., 2016) the clinical literature includes three reports of patients with HIF2-driven disease developing hemangiomas of the retina, liver, and cranial vault (Pacak et al., 2013; Dmitriev et al., 2020; Buffet et al., 2014).