And similarly to the role of HIF2α in liver hemangioma pathogenesis in loss-of-pVHL mouse models, inhibition of HIF2α rescues polycythemia in mouse models of polycythemia driven by the R200W mutation (Ghosh et al., 2021; Hickey et al., 2007; Ghosh et al., 2018). Here, EPAS1 is linked to polycythemia.