EPAS1 and cancer: If our HIF-centric model of pseudohypoxic disease holds then we would expect that Type 2c pVHL mutants would result in similar HIF2α stabilization as Class 1 HIF2α mutants or cancer-causing PHD2 mutants; Type 2a pVHL mutants would result in greater stabilization of HIF2α than either Type 2c pVHL mutants or Class HIF2α mutants; and Type 2b pVHL mutants would result in even greater stabilization of HIF2α.