The human proteome encodes 61 different BRDs belonging to 42 proteins.[1] Among these, the bromodomain and extra terminal (BET) family has been extensively studied, establishing a central role in transcription which is perturbed in several pathological conditions, including cancer and inflammation.[2] The BET family includes four members, BRD2, BRD3, BRD4 and BRDT, each containing two highly homologous N‐terminal bromodomain modules, namely BD1 and BD2, that are responsible for the recognition and binding to KAc (Figure 1). The gene discussed is DEFB1; the disease is cancer.