In prostate cancer cells, for example, the cytosine-rich domain of antisense AR-eRNA, which is predicted to form a stem-loop structure, is key for AR-eRNA function, recruiting DNA methyltransferase 1 (DNMT1) to the associated enhancer to alter the DNA methylation levels of AR target loci (Pan et al., 2021). The gene discussed is AR; the disease is prostate carcinoma.