The interest around the function of BAF at the NE has grown since an alanine to threonine homozygous missense mutation at position 12 (Ala12Thr–BAF A12T) was identified as the cause of a premature aging disorder termed Nestor–Guillermo Progeria Syndrome (NGPS) (39–41). The gene discussed is BANF1; the disease is Nestor-Guillermo progeria syndrome.