Furthermore, multivariate logistic regression revealed that age (OR = 1.154, 95%CI: 1.037–1.285, p = .009), LN activity index (OR = 1.902, 95%CI: 1.107–3.267, p = .020), alopecia (Yes vs. No) (OR = 15.779, 95%CI: 1.466–169.888, p = .023), 24 h proteinuria (OR = 2.131, 95%CI: 1.022–4.446, p = .044), and CRP (OR = 1.075, 95%CI: 1.000–1.155, p = .049) were independently correlated with higher anxiety risk. The gene discussed is CRP; the disease is alopecia.