Antiphospholipid syndrome (APS) is defined as an autoimmune multisystem disease featured by the development of arterial and venous thromboembolic events and/or pathological pregnancies, mainly recurrent abortion, under the condition of persistently positive antiphospholipid antibody (aPL).1, 2, 3. This evidence concerns the gene FASLG and autoimmune polyendocrinopathy.