The anti‐B2GPI levels in the serum of the mouse models in the Control group and APS group were tested by ELISA, and the observation revealed that the anti‐B2GPI levels in the APS group were markedly higher relative to the Control group (Figure 5A, p < .05), indicating that the APS mouse model was successfully constructed. Here, APOH is linked to autoimmune polyendocrinopathy.