MYC and esophageal squamous cell carcinoma: And studies have found that interaction with WDR5 which was a key determinant for MYC recruitment to chromatin, promoted target gene recognition and tumorigenesis by MYC,6 and WDR5 promoted proliferation and correlated with poor prognosis in esophageal squamous cell carcinoma,7 and overexpression of WDR5 associated with aggressive clinicopathological features and unfavorable prognosis in HNSC.8