To investigate theassociation of IRAK-M and TXNIP changes with the development of prediabetes and T2Dand assess the use of IRAK-M and TXNIP as additional indicators of prediabetes andT2D, we measured IRAK-M and TXNIP in patients with various fasting plasma glucose(FPG) levels and determined the cutoff values of IRAK-M and TXNIP for prediabetesand T2D with receiver operating characteristic curve (ROC) analysis. This evidence concerns the gene TXNIP and type 2 diabetes mellitus.