TLR4 and Insulin resistance: Thisconsequently inhibits the production of inflammatory cytokines, subsequentlyimproving local and systemic inflammation and reducing insulin resistance.48 Another study revealed that TLR4 knockout activated TRIF/IRF3 signaling,induced inflammation, and increased the spleen index.49 Studies with TLR2 knockout (Tlr2−/−) micerevealed other possible mechanisms leading to diabetic and obese phenotypes.