The highAUC values for IRAK-M (0.877) and TXNIP (0.872) in prediabetes and IRAK-M (0.983)and TXNIP (0.991) in T2D further suggested that IRAK-M and TXNIP are reliablemarkers of early T2D development. Here, TXNIP is linked to type 2 diabetes mellitus.