Additionally, in this study, we estimated the diagnostic utility of the BMI, HbA1c, insulin, HOMA-IR, eGFR, microalbumin, and serum adiponectin for the early detection of DN by comparing newly diagnosed T2DM patients with normoalbuminuria and healthy controls using ROC curve analysis, as shown in Table 5. The gene discussed is INS; the disease is type 2 diabetes mellitus.