On the other hand, Anindita B et al. reported reduced adiponectin concentrations as an independent risk factor for the progression to prediabetes and T2DM, which might be helpful for developing experimental models as well as identifying biomarkers [4]. In our study, we found a significant inverse association between serum adiponectin and BMI in prediabetic subjects (p = 0.0001**). This states that hypoadiponectinemia may pose the risk of T2DM. This evidence concerns the gene ADIPOQ and prediabetes syndrome.