ADIPOQ and metabolic disease: The factors behind this were found to be advanced lifestyle changes (physical inactivity, food habits), western food habits (low intake of fruits and vegetables and consumption of a high-fat diet and beverages consisting of high sugars), stress, smoking, alcoholism, and metabolic and genetic factors, which lead to systemic and metabolic diseases [22]. Jiang Y et al. suggested that adiponectin levels are a significant marker of incident prediabetes and the development of T2DM [23].