However, the effect of different SGLT2 inhibitors varies among the individual SGLT2 inhibitors, this meta-analysis chose only those studies comparing dapagliflozin and empagliflozin to assess which of these two drugs are more effective in preventing cardiovascular outcomes such as myocardial infarction, stroke, heart failure and cardiac-related death in type 2 diabetes patients. The gene discussed is SLC5A2; the disease is heart failure.