Interestingly, Th17-signature genes are seen to be closely associated with human IBD with common genes presented by them such as the granulopoiesis cytokine GM-CSF (colony-stimulating factor 2 [CSF2]), Th1-associated TFs (T-bet [Tbx21],STAT4), the IL-7 receptor alpha chain (Il7r), and granzyme B (Gzmb) [24]. Here, GZMB is linked to inflammatory bowel disease.