When compared to the 2018 ICM-recommended PJI-optimized thresholds, laboratory-reported normal thresholds resulted in mean false-positive test rates of 14%,18%, 42%, 93%, and 36% for the ESR, CRP, D-dimer, SF-WBC, and SF-PMN%, respectively, for the diagnosis of PJI across laboratories included in this study. The observed mean false-positive rate of laboratory-reported threshold interpretations relative to 2018 ICM-recommended threshold interpretations was clinically significant (>10%) for all laboratory tests considered (Table 5). The gene discussed is CRP; the disease is juvenile polyposis syndrome.