Every test assessed in this study, including the ESR, CRP, D-dimer, SF-WBC, and SF-PMN%, had a mean laboratory-reported normal threshold across clinical laboratories that demonstrated a substantial difference from the 2018 ICM recommendations, being set far below the test thresholds that have been recommended as optimal to diagnose PJI by the 2018 ICM [2]. The gene discussed is CRP; the disease is juvenile polyposis syndrome.