SHANK3 and premenstrual tension: Future work should be done to examine whether sleep disruption during development also contributes to lasting changes in behavior in distinct ASD animal models [60], and in alternative Shank3 mouse models that target different exons within the mouse Shank3 gene, including the recently developed “complete Shank3 deletion” targeting exons 4–22, that better models the chromosomal loss of SHANK3 seen in the majority of PMS patients [25].