Immunostaining showed that E-cadherin expression was higher in mtDNA-depleted ESCC cells injected into mice treated with CDDP combined with zebularine than in those injected into mice treated with other drugs and that the expression of N-cadherin and vimentin was lower in cells injected into mice treated with CDDP combined with zebularine than in cells injected into mice treated with other drugs (Fig. 8C). The gene discussed is CDH2; the disease is esophageal squamous cell carcinoma.