Also in HCC, ACAT1 mediates GNPAT acetylation at K128, which inhibits TRIM21-mediated ubiquitination of GNPAT at K113, K146 and K312 thereby stabilizing GNPAT by excluding the ubiquitylation of these resides and slowing proteasomal degradation [139]. This evidence concerns the gene ACAT1 and hepatocellular carcinoma.