Therefore one of the explanations miR-659-3p inhibits osteosarcoma cells growth, migration and invasion, and osteosarcoma tumor progression is that miR-659-3p increases osteosarcoma cell apoptosis by downregulating SRPK1 expression and further downregulated SRPK1 downstream targets such as PCNA and Ki67. Here, MKI67 is linked to osteosarcoma.