The role of AQP3 has been well studied in kidney diseases that may impair kidney function, generally little is known of its activities in maintenance hemodialysis patients and its influence on the spectrum of clinical symptoms; however, epidermal AQP3 has been proven to be elevated in patients with chronic kidney disease-associated pruritus (CKD-aP) [27]. This evidence concerns the gene AQP3 and chronic kidney disease.