Adipocyte enhancer-binding protein 1 (AEBP1) rises in obesity, causing a drop in PTEN activity and consequent stimulation of adipocyte proliferation in mice [69] and this increase in adipocyte proliferation may lead to further crosstalk between adipocytes and tumour cells, for instance by leptin. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.