CD274 and neoplasm: Standard clinical biomarkers, including PD-L1 tumor proportion score (TPS) and TMB were significantly different between responders and nonresponders in the multimodal cohort; however, classification models using these features were unable to completely separate the two groups (TPS, AUC = 0.73, 95% CI 0.65–0.81; TMB, AUC = 0.61, 95% CI 0.52–0.69; Fig. 1d).