Despite this, the discontinuation rate for SG due to TRAEs for patients with the *28 homozygous genotype was low (6%), and no patients of any UGT1A1 genotype discontinued SG due to SG-related neutropenia or diarrhea, suggesting favorable tolerability when using the current AE management strategies of active monitoring and early intervention (e.g., dose reductions and supportive medication use). The gene discussed is UGT1A1; the disease is Decreased total neutrophil count.