UGT1A1 and neutropenia: Despite this, the discontinuation rate for SG due to TRAEs for patients with the *28 homozygous genotype was low (6%), and no patients of any UGT1A1 genotype discontinued SG due to SG-related neutropenia or diarrhea, suggesting favorable tolerability when using the current AE management strategies of active monitoring and early intervention (e.g., dose reductions and supportive medication use).