Contrary to expectations, the survival analysis of the CST5 mRNA expression data of pancreatic cancer patients (n = 176) from The Cancer Genome Atlas (TCGA) database indicated that the high CST5 expression can be correlated with an unfavorable overall survival rate (p < 0.05) (https://www.proteinatlas.org), which might suggest that CST5 acts as a tumor-promoting factor in pancreatic cancer. Here, CST5 is linked to familial pancreatic carcinoma.