Yan et al. have shown (by using the pancreatic cancer cell-line Panic-1) that the paracrine HGF (via its receptor c-MET activation) can induce a YAP nuclear translocation and an HIF1α stabilization, thereby promoting the expression of cancer stem cell pluripotency markers (including the sex-determining region Y (SRY)-Box2; SOX2) and tumorsphere formation52. The gene discussed is HGF; the disease is familial pancreatic carcinoma.