Hepatocyte-specific Tgfbr2 deficiency (Tgfbr2ΔHEP) prevents choline-deficient amino acid (CDAA)-defined diet-induced steatosis, inflammation, and fibrosis15, and hepatocyte-specific SMAD7 expression blunts CCl4-induced liver fibrosis in mice14. The gene discussed is SMAD7; the disease is steatosis.