To understand the role of cholangiocytic Prom1 in liver fibrosis, we generated cholangiocyte-specific Prom1-deficient mice (Prom1f/f; Krt19-Cre) by crossing Prom1f/f mice (f/f) with transgenic Krt19-Cre mice (Supplementary Fig. 3a). Here, KRT19 is linked to Hepatic fibrosis.