To determine the role of PROM1 in liver fibrosis, we generated liver-specific Prom1-deficient mice (Prom1f/f; Alb-Cre) by crossing Prom1f/f mice (f/f) containing two loxP sequences flanking exon 2 of Prom1 with Alb-Cre transgenic mice (Alb-Cre) (Supplementary Fig. 2a, b). This evidence concerns the gene ALB and Hepatic fibrosis.