Interestingly, several other HDAC1/7-SE upregulated targets, such as SNPH, CCANG4, PREX1, IGFBP5, IL34 and BCAS4 also demonstrate remarkable level of breast cancer associated over-expression, providing additional support for the relevance of the ET-125 signature (Supplementary Fig. 3). This evidence concerns the gene IGFBP5 and breast carcinoma.