In addition, the regulation of tumor-macrophage interactions by EZH2-miR-124-3p-CCL2 axis as uncovered in our study demonstrated that blockade of cytokines not only had direct intrinsic inhibitory effect on tumor cells, but also educated the TME toward an anti-tumor phenotype by altering the relative proportion between pro-tumor and anti-tumor macrophages or other immune cells. This evidence concerns the gene CCL2 and neoplasm.