It has been reported that CAFs promote hepatocellular carcinoma angiogenesis and metastasis through VEGF-induced upregulation of EZH2 and subsequent downregulation of vasohibin 1, a negative regulator of angiogenesis, emphasizing an important role of EZH2 in mediating the function of CAFs [64]. This evidence concerns the gene VASH1 and hepatocellular carcinoma.