Consistently, other study reports that EZH2-mediated H3K27me3 and DNMT1-mediated DNA methylation inhibit the expression of tumor-derived T helper 1 (TH1)-type chemokines CXCL9 and CXCL10, and treatment with epigenetic modulators gets rid of the suppression, promotes tumor-infiltrating effector T-cells and strengthens the therapeutic efficacy of programmed death-ligand 1 (PD-L1) checkpoint blockade [66]. The gene discussed is CD274; the disease is neoplasm.