To further investigate the roles of LINC00239 and Keap1/Nrf2 signal pathway in CRC, we detected the expression of LINC00239 and Nrf2 target gene (GPX4, GCLM, GCLC, FTH1, HO-1, and NQO1 in fresh CRC samples. The gene discussed is GCLC; the disease is colorectal carcinoma.