Reviews of the mechanism of action of lithium note a wide range of effects (such as upregulation of adenyl cyclase, cyclic adenosine monophosphate, brain-derived neurotrophic factor (BDNF), and bcl-2, and downregulation of sodium myo-inositol transporter, protein kinase C, and myristoylated alanine-rich C-kinase (MARCKS)) but the inhibitory effects of lithium on GSK3 and the phosphatidylinositol cycle (PI-cycle) have emerged as the leading hypotheses for therapeutic effects in BD [15]. This evidence concerns the gene BDNF and Behcet disease.