As shown in Fig. 2A, compared with the control group, after CA treatment, we screened out three co-upregulated genes, namely HERPUD1, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), growth differentiation factor 15 (GDF15) through transcriptome sequencing technology and tandem mass tags (TMT). The gene discussed is GDF15; the disease is cancer.