TP53 and cancer: In a review published by Rebecca et al. in 2011, five ways in which cancer cells evade apoptosis were described: (1) the reduced expression of death receptors in cancer cells, (2) a high expression of proteins that antagonize apoptosis (e.g., Bcl-2), and (3) Overexpression of proteins associated with inhibition of apoptosis (e.g., IAP); (4) A reduced expression of caspases and (5) p53 mutations [24].