In 2019 Nature, Weiping Zou et al. found that γ-IFN released from CD8+ T cells promotes ferroptosis in cancer cells by inhibiting System Xc− and that the combination of PD-L1 and activators of ferroptosis enhances the killing effect of CD8+ T on tumor cells, thereby promoting tumor therapy [59]. The gene discussed is CD8A; the disease is neoplasm.