MAP2K7 and metastatic melanoma: As a first attempt to test if this might be relevant in the clinical setting, we used a small cohort of nine human metastatic melanoma patients who were treated with vemurafenib alone or in combination with MEK inhibitors, and from whom pre-treatment and relapse histological samples were available from previous studies (Frederick et al, 2013) (Figs 6, S5, and S6 and Table 1).