For example, the bone sialoprotein binding protein (a product of the bbp gene) is a bacterial cell wall protein that binds to matrix molecules on bone, antibodies to which correlate with the presence of osteomyelitis in adults [10], while mutations in the collagen binding adhesion gene (cna) in S. aureus render the organism significantly less able to produce osteomyelitis in a murine model of the disease [11]. This evidence concerns the gene PPP3CA and osteomyelitis.