STING1 and COVID-19: The interferon signaling pathways, and the increased expression of interferon-stimulated genes (ISG) in COVID-19 patient lung tissues implicate the critical role of interferon in SARS-CoV-2 pathogenesis, but it has not been determined if the cytokines contribute more to suppressing viral replication, or augmenting the immune response through their dual pro- or anti-inflammatory abilities, thus contributing to greater disease [50, 51].