Binding of phage protein gp12 to the hydrophilic core disturbed its function in the formation of TLR4-MD-2-LPS complexes that could lead to immune stimulation.108 Phages reduce the production of inflammatory mediators, which may reduce the development of GVHD and have a protective effect against GVHD in the clinic. The gene discussed is LY96; the disease is graft versus host disease.