Duan Y et al. (2019) compared patients with alcoholic hepatitis, subjects with alcohol use disorders, and healthy controls and found a more than 2,700-fold increase in the number of E. faecalis in the gut microflora of the alcoholic hepatitis group.37 Thirty percent of E. faecalis strains have genes that encode an exotoxin called cytolysin. Here, PRF1 is linked to alcoholic hepatitis.