Interestingly, this inducible construct did not lead to an increase in CDK1NC expression in vitro (Fig. S7A), but did lead to an increase in CDKN1C in vivo (see ahead to Fig. 4C), suggesting that other forces including but not limited to intensity and duration of knockdown, and potentially tumor microenvironment may impact the efficacy of the dox‐inducible system. This evidence concerns the gene CDKN1C and neoplasm.