Of the measured genes, CX3CR1, SYT11, TGFBR3, FGFBP2, and NKG7 were increased in the HIV‐infected group compared with the control groups, including older frail individuals, suggesting that the upregulation of these genes is likely related to HIV infection but not to aging alone or general health status. This evidence concerns the gene FGFBP2 and HIV infectious disease.