Cytoadhesion of iRBCs to brain capillaries is thought to be a critical step leading to the disruption of the BBB, since specific PfEMP1 variants expressed on the surface of iRBCs that bind receptors on the brain endothelium, such as ICAM-1 and EPCR, are found in CM patients (5). The gene discussed is ICAM1; the disease is cutaneous mastocytosis.