The most common (≥ 30%) any-grade TEAEs were increased blood creatine phosphokinase (CPK; 81%), hypertension (59%), diarrhea (47%), increased aspartate aminotransferase (AST; 44%), stomatitis (44%), increased lipase (34%), increased amylase (34%), and increased alanine aminotransferase (ALT; 34%). This evidence concerns the gene PIK3C2A and hypertensive disorder.