USP10 and Myocardial fibrosis: Increased exercise (56–66% of VO2max for 4 weeks)-induced Follistatin-like protein 1 (FSTL1) secretion through the FSTL1-USP10-Notch1 signaling axis has been reported to inhibit myocardial fibrosis in diabetic rats (Xi et al., 2016; Lu et al., 2021) (Table 2).