Aerobic exercise (48% of VO2max for 6 weeks) also significantly reduces oxidative stress (H2O2) and apoptosis by activating the Fibroblast growth factor 21 (FGF-21)/FGFR1/PI3K/AKT pathway, which ultimately improves heart function in mice with myocardial infarction (Bo et al., 2021a) (Figure 1) (Table 1). This evidence concerns the gene AKT1 and myocardial infarction.