Song et al. found that excessive neutrophil extracellular traps (NETS) led to severe inflammation and increased the levels of M1 markers including IL-6, IL-1β, TNF-α, and Myeloperoxidase (MPO) in BALF, suggesting that NETS can promote ARDS inflammation in the acute phase (Song et al., 2019). The gene discussed is MPO; the disease is acute respiratory distress syndrome.