The secreted phosphoprotein 1 (SPP1) is an integrin-binding phosphorylated glycoprotein that has been reported to play important roles in several tumor-associated processes, including proliferation, invasion, migration, angiogenesis, and metastasis (Huang et al., 2017; Zeng et al., 2018; Chiou et al., 2019). This evidence concerns the gene SPP1 and neoplasm.