The PI3K/Akt signaling pathway is aberrantly activated in most malignancies and activated AKT phosphorylates downstream target proteins, including FOXO1, WEE1, GSK3b, and mTORC1, which lead to tumor cell survival, promote cell cycle progression, ribosome biogenesis or protein synthesis (Song et al., 2019). This evidence concerns the gene AKT1 and neoplasm.