HSP70-bim PPI inhibits apoptosis by regulating the folding of oncogenic clients AKT and Raf-1 in cancer cells (Guo et al., 2020), whereas S1g-6, an HSP70 inhibitor targeting the tumor-associated HSP70-Bim PPI, significantly decreased the expression and phosphorylation levels of AKT and Raf-1 proteins when BV173 and KCL22 cells in CML cell lines were treated with S1g-6 (Wang et al., 2021). This evidence concerns the gene AKT1 and cancer.