HSPA5 and neoplasm: Further studies also showed that GRP78 (HSP70) knockdown significantly inhibited VEGF-induced endothelial cell proliferation and VEGF-induced extracellular regulated protein kinase 1/2 (ERK1/2), phospholipase C-γ (PLC-γ), and VEGFR-2 phosphorylation, thereby suppressing tumour angiogenesis (Katanasaka et al., 2010).