HSPA5 and nasopharyngeal carcinoma: HSP70 inhibitors can radiosensitize tumors by inhibiting HSP70-induced cell cycle checkpoint arrest, as in nasopharyngeal carcinoma TPL can trigger apoptosis and induce G2/M phase arrest by inhibiting GRP78, thus TPL can be used as a new radiosensitizer for the treatment of nasopharyngeal carcinoma (Li et al., 2016).