Recently, repeat-targeted nucleic acids (L. Li et al., 2016; Shen et al., 2019; Shen et al., 2020) and synthetic transcription elongation factors (Syn-TEFs) (Erwin et al., 2017) were used to elevate FXN expression in FRDA iPSC-based models. This evidence concerns the gene FXN and Friedreich ataxia.