SETD2 and cancer: Expression of the SETD2 shorter splice variant with transcript ID ENST00000638947.1 might lead to similar perturbations in the H3K36me3 profile to what was observed upon expression of SETD2 C. Also, the missense and truncation mutations found in SETD2 in cancers can potentially alter half-life, leading to aberrant H3K36me3 deposition (Supplementary Figure S3).