SETD2 and cancer: SETD2 is frequently mutated in cancers such as CCRCC (Clear Cell Renal Cell Carcinoma), and its deletion is embryonically lethal (Al Sarakbi et al., 2009; Duns et al., 2010; Hu et al., 2010; Zhu et al., 2014; Li et al., 2016a; Su et al., 2017; Chiang et al., 2018).